Time/Place: TuTh 9:30-11:30 a.m. MUE 155 (subject to change)
Partially supported by GEMSEC:
Genetically Engineered Materials Science & Engineering Center
Instructor: Prof. Mehmet Sarikaya
sarikaya@u.washington.edu
Topics to be discussed may include:
- Combinatorial in vitro and in vivo peptide selection
- Post-selection Protein Engineering
- Peptide binding: Assembly, Kinetics & Thermodynamics
- Molecular Structure: Experimental
(NMR, AFM, CD, FTIR, Spectroscopy)
- Molecular Structure via Computational Modeling
- Bioinformatics for Protein/Peptide Design
- Hybrid Molecular Constructs
- Designer/Designed Protein-Based
Molecular Templates
- Peptides/proteins as:
- Molecular Erectors
- Molecular Assemblers
- Genetic Linkers
- Molecular (Cancer) Probes
- Designed Molecular Matrices
for Tissue Engineering
- Peptide Amphiphiles for Regenerative Medicine
- Self-assembled Nanostructures (DNA, proteins, Peptide)
- Bio-nanotechnology- nano-electronics, -photonics, and -magnetics
The Labs & Hands-on Experience - 5 Lab experiments on:
- Phage and Cell Surface Display
- Biomolecular Adsorption: ELISA, QCM, SPR, etc.
- Biomineralizing Hydrogels (scaffolds for tissue regeneration
- Cell culture studies:
- Self-assembled peptides (SAPs) - Formation (AFM/STM) & Utility (peptide-Nanowires)
- Peptide-enabled nano-Devices (bionanosensors, gFET: graphene field effect transistors)
The Classes ..
- Will be presented by the instructor and invited UW and prominent outside speakers from diverse disciplines,
- Will be in the form of informal presentations and discussions,
- Will include supplementary material (handouts, published papers, video)
- The course requirement will include short lab reports & a full proposal (prepared via NSF or NIH format) or a formal publishable paper based on student/post-doc research area that uses designed peptide or protein towards nanotechnology, bionanotechnology, or medical
