MSE 599 Biomaterials/Nanomaterials in Tissue Engineering

(Credits: 3, Winter 2012, W 3:30-6.20 pm, Low105)
Instructor: Miqin Zhang
Professor, Department of Materials Science and Engineering,
Adjunct professor, Departments of Neurological Surgery, Orthopaedics and Sports Medicine, and
Radiology
University of Washington
Office: 302L Roberts Hall
Tel: (206) 616-9356
Fax: (206) 543-3100
Email: mzhang@u.washington.edu

Course website: http://faculty.washington.edu/mzhang/mse599/mse599.html
http://faculty.washington.edu/mzhang

Course Description
The objective of this course is to provide students a fundamental understanding of
biomaterials, implant applications, and their design consideration. This course covers the
fundamentals of the synthesis, properties, and biocompatibility of metallic, ceramic,
polymeric, composite, and biological materials, and their applications for both hard and
soft tissue replacement, and controlled drug delivery. This course will also provide
students a broad understanding of cutting edge development in nanomaterials and their
potential applications in tissue engineering. The course is intended for undergraduate
senior/graduate students.

Course outline
1. Introduction : (1.5 week)
Introduction to biomaterials
The structures of materials
Characterization of materials
2. Classes of biomaterials (1.5 weeks)
Metals
Ceramics
Polymers
Composites
Biological materials
3. Tissue response to materials (1 week)
Host response to biomaterial
Material response to host
Biocompatibility of materials
4. Biomaterials (2 weeks)
Soft tissue replacement I: sutures, skin, maxillofacial implants
Soft tissue replacement II: Blood interfacing implants
Hard tissue replacement I: long bone repair
Hard tissue replacement II: joints and teeth
Transplants
Biomaterials in Tissue Engineering
5. Nanomaterials in tissue engineering (4 weeks)
Nanomaterials-cell interactions
Electrospinning technology for nanofibrous scaffolds
Nanomaterials for skeletal, muscle, nerve, and heart tissue engineering
Nanomaterials for stem cell tissue engineering
Nanomaterials for drug delivery
Magnetic nanoparticles for tissue engineering
Nanoparticles/nanotubes/nanowires for cellular engineering

Textbooks
Biomaterials An Introduction, Joon B. Park and Roderic S. Lakes, 3nd Edition, Plenum
Press 2007.

Reference books
Materials Science and Engineering an Introduction, William D Callister, Jr., 6th,
or 7th or 8th Edition
Biomaterials Science: An Introduction to Materials in Medicine, 2nd Edition.
Buddy Ratner, Allan S. Hoffman, Frederick J. Schoen, and Jack E. Lemons,
Academic Press, 2004.
Frontiers in Tissue Engineering, Edited by Charles W. Patrick Jr, Antonios G.
Mikos, and Larry V. McIntire, Pergamon, 2011.
Nanotechnologies for the Life Science, Tissue, Cell, Organ Engineering, Edited
by Challa Kumar, Wiley-VCH, 2008.
Nanotechnology and Tissue Engineering: The Scaffold, Cato Laurencin, Lakshmi
Nair, CRC Press, 2008.
The Handbook of Nanomedicine, Kewal Jain, Springer, 2008.

Homework and exams
Homework assignments
Term paper and project presentation
Take-home final

Grading
Homework 20%
Abstract and outline of a term paper 20%
Presentation 20%
Final (Term paper) 40%

Schedule
First day of class: Wed, Jan 4
Abstract and outline of the term paper: Wed, Feb 1
First draft of the term paper by email: Wed, Feb 29
Project presentation: Wed, March 7
Final draft of the term paper by email: Friday, March 9